Effects of Stromal Vascular Fraction and Platelet-Rich Plasma Treatment on Capillary Histopathology During Anal Trauma Healing in Rats: An in Vivo Study

INTRODUCTION: Anal traumas, such as blunt and penetrating injuries to the perineum, can disrupt anal sphincter cause considerable morbidity. Non-invasive trauma therapies have been widely developed, including growth factors administered platelet-rich plasma (PRP) stromal vascular fraction (SVFs) containing adipose[1]derived stem cells (ASCs) limited factor. This study aimed assess PRP SVF effects on capillary histopathology in Wistar rat model. MATERIALS AND METHODS: experimental used a Rats were divided into three groups: Group A (n=12) was treated with SVFs; B normal saline (placebo); C (n=4) sacrificed day 0 obtain baseline counts. Groups further subgroups, days 1, 7, 14 post-treatment. RESULTS: Capillary counts significantly showed higher density between (p=0.037, analysis of variance). On there significant difference (p=0.001). CONCLUSION: Mean improved combination SVFs compared control. Our findings support use aid recovery patients trauma.